| Description |
Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability[1][2].
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| Related Catalog |
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| Target |
Kd: 20 nM (KCa channel)[1]
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| In Vitro |
Kaliotoxin (KTX) (250 nM) specifically suppressed the whole cell Ca2+-activated K+ current[1]. Kaliotoxin interacts in a one-to-one way with KCa channels with a Kd of 20 nM[1].
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| In Vivo |
Kaliotoxin facilitates cognitive processes by the blockage of Kv1.1 or Kv1.3 channels[2]. Animal Model: Male Sprague–Dawley rats (280–300 g)[2] Dosage: 10 ng Administration: Intracerebroventricular injection Result: Improved learning but not information consolidation. Increased the long-term retrieval of an odour-reward association.
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