1404562-17-9

1404562-17-9 structure

Name: BRD6688
Chemical Name: N-[2-Amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide
CAS Number: 1404562-17-9
Molecular Formula: C₁₆H₁₈N₄O
Molecular Weight: 282.340
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2018-06-27 00:08:35
Modify Date: 2024-01-06 07:38:11
BRD6688 is a selective HDAC2 inhibitor. BRD6688 increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cells. BRD6688 crosses the blood brain barrier and rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model[1].

Name	N-[2-Amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide
Synonyms	N-[2-Amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide 1-Pyrrolidinecarboxamide, N-[2-amino-5-(4-pyridinyl)phenyl]-

Description	BRD6688 is a selective HDAC2 inhibitor. BRD6688 increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cells. BRD6688 crosses the blood brain barrier and rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC2
References	[1]. Wagner FF, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015 Jan 1;6(1):804-815.