193807-58-8

193807-58-8 structure

Name: gelatinase a
Chemical Name: N-(4-Biphenylylsulfonyl)-D-phenylalanine
CAS Number: 193807-58-8
Molecular Formula: C₂₁H₁₉NO₄S
Molecular Weight: 381.445
Catalog: Biochemical Enzymes and coenzymes
Create Date: 2018-07-05 00:23:15
Modify Date: 2024-01-14 17:51:41
MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer[1].

Name	N-(4-Biphenylylsulfonyl)-D-phenylalanine
Synonyms	D-Phenylalanine, N-([1,1'-biphenyl]-4-ylsulfonyl)- N-(Biphenyl-4-ylsulfonyl)-D-phenylalanine N-(4-Biphenylylsulfonyl)-D-phenylalanine

Description	MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
References	[1]. Y Tamura, et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J Med Chem. 1998 Feb 12;41(4):640-9.