287405-51-0

287405-51-0 structure

Name: Apratastat
Chemical Name: Apratastat
CAS Number: 287405-51-0
Molecular Formula: C₁₇H₂₂N₂O₆S₂
Molecular Weight: 414.496
Catalog: Signaling Pathways Apoptosis TNF Receptor
Create Date: 2018-06-03 20:30:05
Modify Date: 2025-08-24 22:29:16
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) . Apratastat can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].

Name	Apratastat
Synonyms	(3S)-N-Hydroxy-4-({4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl}sulfonyl)-2,2-dimethyl-3-thiomorpholinecarboxamide TMI 005 (3S)-N-hydroxy-4-({4-[(4-hydroxybut-2-yn-1-yl)oxy]phenyl}sulfonyl)-2,2-dimethylthiomorpholine-3-carboxamide MFCD13152357 3-Thiomorpholinecarboxamide, N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-, (3S)- Apratastat

Description	Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) . Apratastat can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> TNF Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	TNF-α MMP
References	[1]. Shu C, et al. Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach. J Clin Pharmacol. 2011 Apr;51(4):472-81.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xi
RIDADR	NONH for all modes of transport