66611-27-6

66611-27-6 structure

Name: RU 24969 hemisuccinate
Chemical Name: 5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate (2:1)
CAS Number: 66611-27-6
Molecular Formula: C₃₂H₃₈N₄O₆
Molecular Weight: 574.667
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-07-13 18:11:18
Modify Date: 2025-08-27 09:49:51
RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1].

Name	5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate (2:1)
Synonyms	5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate (2:1) MFCD09878262 1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, butanedioate (2:1) Succinic acid - 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:2)

Description	RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1B Receptor:0.38 nM (Ki) 5-HT1A Receptor:2.5 nM (Ki)
In Vitro	RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].
In Vivo	RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1]. RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg Administration: A single s.c. Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
References	[1]. Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4. [2]. Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16.