1580000-17-4

1580000-17-4 structure

Name: OS-3-106
Chemical Name: N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-4-(1,3-thiazol-4-yl)benzamide
CAS Number: 1580000-17-4
Molecular Formula: C₂₅H₃₀N₄O₂S
Molecular Weight: 450.60
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-07-13 03:05:38
Modify Date: 2024-01-08 22:22:39
OS-3-106 is a potent, BBB-penetrated and selective dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (Ki = 0.2 nM) at the D3R. OS-3-106 reduces cocaine self-administration and sucrose reinforcement rates. OS-3-106 can be used for psychostimulant addiction research[1].

Name	N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-4-(1,3-thiazol-4-yl)benzamide
Synonyms	MFCD28118985 N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-4-(1,3-thiazol-4-yl)benzamide Benzamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-4-(4-thiazolyl)-

Description	OS-3-106 is a potent, BBB-penetrated and selective dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (Ki = 0.2 nM) at the D3R. OS-3-106 reduces cocaine self-administration and sucrose reinforcement rates. OS-3-106 can be used for psychostimulant addiction research[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D3 Receptor:0.2 nM (Ki) D2 Receptor
In Vitro	OS-3-106 exhibits 115-fold binding selectivity for the D3R compared with the D2R[1].
References	[1]. Cheung TH, et al. Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55. J Pharmacol Exp Ther. 2013 Nov;347(2):410-23.