1000578-26-6
1000578-26-6 structure
- Name: AS 19
- Chemical Name: AS-19
- CAS Number: 1000578-26-6
- Molecular Formula: C18H25N3
- Molecular Weight: 283.411
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-06-24 15:08:41
- Modify Date: 2024-01-08 18:37:49
-
AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia[1][2][3].
| Name | AS-19 |
|---|---|
| Synonyms |
2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)-
(2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-2-naphthalenamine (2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine AS-19 |
| Description | AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
Human 5-HT7 Receptor:0.83 nM (IC50) Human 5-HT7 Receptor:0.6 nM (Ki) 5-HT1A Receptor:89.7 nM (Ki) 5-HT1B Receptor:490 nM (Ki) 5-HT1D Receptor:6.6 nM (Ki) 5-HT5 Receptor:98.5 nM (Ki) |
| In Vitro | The proliferation of T-cell from parachlorophenylalanine-treated mice is significantly reduced, addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours[2]. |
| In Vivo | AS19 (0.5-10 mg/kg; subcutaneous injection; for 24 hours; male Wistar rats) treatment improves memory consolidation in an autoshaping Pavlovian/instrumental learning task[1]. Animal Model: Male Wistar rats (12-week-old) with autoshaping Pavlovian/instrumental learning task[1] Dosage: 0.5 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg Administration: Subcutaneous injection; for 24 hours Result: Enhanced memory formation in an autoshaping Pavlovian/instrumental learning task. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 413.3±45.0 °C at 760 mmHg |
| Molecular Formula | C18H25N3 |
| Molecular Weight | 283.411 |
| Flash Point | 203.7±28.7 °C |
| Exact Mass | 283.204834 |
| LogP | 3.71 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
|---|