1433497-19-8
1433497-19-8 structure
- Name: LY 2955303
- Chemical Name: LY2955303
- CAS Number: 1433497-19-8
- Molecular Formula: C36H42N4O3
- Molecular Weight: 578.74
- Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
- Create Date: 2018-01-04 18:44:38
- Modify Date: 2024-01-27 18:12:18
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LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.
| Name | LY2955303 |
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| Description | LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM. |
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| Related Catalog | |
| Target |
Ki: 1.09 nM (RARγ)[1] |
| In Vitro | LY2955303 is tested and observed that the binding Kis for RARα, RARβ and RARγ are >1700, >2980 and 1.09 nM, respectively. The functional Ki for RARγ is 7.1±4.9 nM[1]. |
| In Vivo | A single oral dose of LY2955303 demonstrates a dose responsive effect whereby the rat reduces differential weight bearing (ED50=0.72 mg/kg)[1]. |
| References |
| Molecular Formula | C36H42N4O3 |
|---|---|
| Molecular Weight | 578.74 |
| Storage condition | 2-8℃ |
| Hazard Codes | Xn |
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