1418131-46-0

1418131-46-0 structure

Name: RSC 133
Chemical Name: 3-{[(2E)-3-(1H-Indol-3-yl)-2-propenoyl]amino}benzamide
CAS Number: 1418131-46-0
Molecular Formula: C₁₈H₁₅N₃O₂
Molecular Weight: 305.331
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2018-01-15 11:45:22
Modify Date: 2024-01-11 17:11:29
RSC133 exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. RSC133 effectively facilitates reprogramming of human somatic cells to pluripotent stem cells and supports the maintenance of an undifferentiated state of human pluripotent stem cells[1].

Name	3-{[(2E)-3-(1H-Indol-3-yl)-2-propenoyl]amino}benzamide
Synonyms	3-{[(2E)-3-(1H-Indol-3-yl)-2-propenoyl]amino}benzamide Benzamide, 3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]- RSC 133

Description	RSC133 exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. RSC133 effectively facilitates reprogramming of human somatic cells to pluripotent stem cells and supports the maintenance of an undifferentiated state of human pluripotent stem cells[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Epigenetics >> DNA Methyltransferase
References	[1]. Lee J, et al. A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12509-13.