204395-52-8

204395-52-8 structure

Name: Clozapine-d4
Chemical Name: 8-Chloro-11-[4-methyl(2,2,6,6-2H4)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine
CAS Number: 204395-52-8
Molecular Formula: C₁₈H₁₅D₄ClN₄
Molecular Weight: 330.848
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-06-12 14:22:59
Modify Date: 2024-01-03 12:21:39
Clozapine-d4 (HF 1854-d4) is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].

Name	8-Chloro-11-[4-methyl(2,2,6,6-2H4)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine
Synonyms	8-Chloro-11-[4-methyl(2,2,6,6-H)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,6,6-d)- 8-Chloro-11-[4-methyl(2,2,6,6-H)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine

Description	Clozapine-d4 (HF 1854-d4) is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. [3]. Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40. [4]. Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26. [5]. Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2.

Density	1.3±0.1 g/cm3
Boiling Point	489.2±55.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₅D₄ClN₄
Molecular Weight	330.848
Flash Point	249.6±31.5 °C
Exact Mass	330.154938
LogP	2.36
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.681

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution

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