27964-99-4

27964-99-4 structure

Name: Poly-D-lysine hydrobromide (MW 30000-70000)
Chemical Name: Lysine hydrobromide (1:1)
CAS Number: 27964-99-4
Molecular Formula: (C₆H₁₄N₂O₂)x_.xBrH
Molecular Weight: 30000-70000
Catalog: Biochemical Amino acids and their derivatives Lysine derivative
Create Date: 2018-03-07 17:10:18
Modify Date: 2024-01-02 18:49:04
Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC[1][2].

Name	Lysine hydrobromide (1:1)
Synonyms	MFCD00131934 Lysine hydrobromide (1:1) Lysine, hydrobromide (1:1)

Description	Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Poly-D-lysine is immunogenic in rabbits only when injected at low doses[1]. The approximate concentration of Poly-D-lysine (PDL) needed to lower the amount of PrPres by 50% corresponds to ~0.8 μg/mL or 50 nM[2].
References	[1]. HansVermeersch, et al. Immunogenicity of poly-D-lysine, a potential polymeric drug carrier. Journal of Controlled Release. Volume 32, Issue 3, 1 December 1994, Pages 225-229. [2]. Zhou Xu, et al. Mechanistic insights into cellular alteration of prion by poly-D-lysine: the role of H2H3 domain. FASEB J. 2011 Oct;25(10):3426-35.

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