1061337-51-6

1061337-51-6 structure

Name: Lefamulin(BC-3781)
Chemical Name: bc-3781
CAS Number: 1061337-51-6
Molecular Formula: C₂₈H₄₅NO₅S
Molecular Weight: 507.72600
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-02-16 20:51:46
Modify Date: 2024-01-09 16:56:14
Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia[1].

Name	bc-3781
Synonyms	14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

Description	Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Lefamulin (0-1 mg/L) shows inhibitory activity against C. trachomatis, N. gonorrhoeae, and M. genitalium[2]. Lefamulin shows potent activity against all M. pneumoniae strains with MIC values of ≤0.008 μg/mL[3]. Cell Viability Assay[1] Cell Line: C. trachomatis, N. gonorrhoeae, and M. genitalium Concentration: 0-1 mg/L Incubation Time: Result: Inhibited bacterial activity with MIC50s of 0.02 mg/L, 0.063 mg/L and 0.12 mg/L respectively.
In Vivo	Lefamulin (10-140 mg/kg, s.c.) shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model[4]. Lefamulin (1.25-160 mg/kg, s.c.) shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice[5]. Animal Model: LPS-induced lung neutrophilia mouse model[4] Dosage: 10-140 mg/kg Administration: Subcutaneous injection (s.c.) Result: Reduced BALF neutrophil cell counts. Reduced pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, and GM-CSF), chemokine (CXCL-1, CXCL-2, and CCL-2) and MMP-9 levels in mouse lung tissue.