1206101-20-3
1206101-20-3 structure
- Name: GLPG0634
- Chemical Name: N-(5-{4-[(6-Cyano-3-pyridinyl)methoxy]phenyl}[1,2,4]triazolo[1,5- a]pyridin-2-yl)cyclopropanecarboxamide
- CAS Number: 1206101-20-3
- Molecular Formula: C23H18N6O2
- Molecular Weight: 410.428
- Catalog: Biochemical Inhibitor Tyrosine protein kinase/signal transducer and transcriptional activator inhibitor (JAK/STAT) JAK inhibitor
- Create Date: 2018-12-22 16:59:49
- Modify Date: 2024-01-02 16:01:59
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GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents.
| Name | N-(5-{4-[(6-Cyano-3-pyridinyl)methoxy]phenyl}[1,2,4]triazolo[1,5- a]pyridin-2-yl)cyclopropanecarboxamide |
|---|---|
| Synonyms |
N-(5-{4-[(6-Cyano-3-pyridinyl)methoxy]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
Cyclopropanecarboxamide, N-[5-[4-[(6-cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]- GLPG0634 GLPG0634 analogue GLPG0634 analog |
| Description | GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents. |
|---|---|
| Related Catalog | |
| Target |
JAK3:<100 nM (IC50) Tyk2:<100 nM (IC50) |
| References |
[1]. http://www.google.com/patents/WO2013173506A2cl=en |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H18N6O2 |
| Molecular Weight | 410.428 |
| Exact Mass | 410.149109 |
| PSA | 108.43000 |
| LogP | 2.26 |
| Index of Refraction | 1.733 |
| Storage condition | -20℃ |
| Hazard Codes | Xi |
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~%
1206101-20-3 |
| Literature: Menet, Christel Jeanne Marie; Blanc, Javier Patent: US2010/29709 A1, 2010 ; Location in patent: Page/Page column 26 ; |
| Precursor 1 | |
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| DownStream 0 | |