GLPG0634
Modify Date: 2025-08-20 14:37:49
GLPG0634 structure
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Common Name | GLPG0634 | ||
|---|---|---|---|---|
| CAS Number | 1206101-20-3 | Molecular Weight | 410.428 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H18N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GLPG0634GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents. |
| Name | N-(5-{4-[(6-Cyano-3-pyridinyl)methoxy]phenyl}[1,2,4]triazolo[1,5- a]pyridin-2-yl)cyclopropanecarboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents. |
|---|---|
| Related Catalog | |
| Target |
JAK3:<100 nM (IC50) Tyk2:<100 nM (IC50) |
| References |
[1]. http://www.google.com/patents/WO2013173506A2cl=en |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H18N6O2 |
| Molecular Weight | 410.428 |
| Exact Mass | 410.149109 |
| PSA | 108.43000 |
| LogP | 2.26 |
| Index of Refraction | 1.733 |
| Storage condition | -20℃ |
| Hazard Codes | Xi |
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~%
GLPG0634 CAS#:1206101-20-3 |
| Literature: Menet, Christel Jeanne Marie; Blanc, Javier Patent: US2010/29709 A1, 2010 ; Location in patent: Page/Page column 26 ; |
![N-(5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide structure](https://image.chemsrc.com/caspic/176/1142943-96-1.png)
![5-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-pyridine-2-carbonitrile structure](https://image.chemsrc.com/caspic/440/1206101-28-1.png)
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| N-(5-{4-[(6-Cyano-3-pyridinyl)methoxy]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide |
| Cyclopropanecarboxamide, N-[5-[4-[(6-cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]- |
| GLPG0634 |
| GLPG0634 analogue |
| GLPG0634 analog |