152406-28-5

152406-28-5 structure

Name: Agelastatin A
Chemical Name: (−)-agelastatin A
CAS Number: 152406-28-5
Molecular Formula: C₁₂H₁₃BrN₄O₃
Molecular Weight: 341.16100
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-10 12:20:48
Modify Date: 2025-08-21 12:19:34
Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity[1].

Name	(−)-agelastatin A
Synonyms	(5aS,5bS,8aS,9aR)-1-Bromo-8a-hydroxy-8-methyl-5,5a,5b,6,8,8a,9,9a-octahydroimidazo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazine-4,7-dione agelastatin A Imidazo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazine-4,7-dione, 1-bromo-5,5a,5b,6,8,8a,9,9a-octahydro-8a-hydroxy-8-methyl-, (5aS,5bS,8aS,9aR)-

Description	Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Agelastatin A(0-2 μM, 48 h) 作用于 U-937、HeLa、A549、BT549 以及 IMR90 细胞的 IC50值分别是 67 nM, 708 nM, 1.05 μM, 278 nM 和 1.11 μM[1]。 Agelastatin A(0-1 μM, 48 h) 作用于 CEM、Jurkat、Daudi、HL-60 和 CA46 细胞的 IC50值分别是20，74，20，138 和187 nM[1]。 Agelastatin A(0-150 nM, 16 h)可以剂量依赖性的诱导U-937细胞周期停滞在 G2/M 期[1]。
In Vivo	The pharmacokinetic parameters of Agelastatin A(1a) a single 2.5 mg/kg dose in mice[2]. Parameter/td> intravenous (IV) intraperitoneal (IP) ACU 1742 2946 Cmax 4.5 μM 1.65 μM Tmax 2 min 30 min t1/2 4 min 1 h
References	[1]. Sunkyu Han, et al. Synthesis and anticancer activity of all known (-)-agelastatin alkaloids. J Org Chem. 2013 Dec 6;78(23):11970-84. [2]. E Paige Stout, et al. Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies. J Med Chem. 2014 Jun 26;57(12):5085-93. doi: 10.1021/jm4016922. Epub 2014 Jun.