Agelastatin A
Modify Date: 2025-08-21 12:19:34
Agelastatin A structure
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Common Name | Agelastatin A | ||
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| CAS Number | 152406-28-5 | Molecular Weight | 341.16100 | |
| Density | 2.2±0.1 g/cm3 | Boiling Point | 760.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C12H13BrN4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 413.9±32.9 °C | |
Use of Agelastatin AAgelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity[1]. |
| Name | (−)-agelastatin A |
|---|---|
| Synonym | More Synonyms |
| Description | Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity[1]. |
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| Related Catalog | |
| In Vitro | Agelastatin A(0-2 μM, 48 h) 作用于 U-937、HeLa、A549、BT549 以及 IMR90 细胞的 IC50值分别是 67 nM, 708 nM, 1.05 μM, 278 nM 和 1.11 μM[1]。 Agelastatin A(0-1 μM, 48 h) 作用于 CEM、Jurkat、Daudi、HL-60 和 CA46 细胞的 IC50值分别是20，74，20，138 和187 nM[1]。 Agelastatin A(0-150 nM, 16 h)可以剂量依赖性的诱导U-937细胞周期停滞在 G2/M 期[1]。 |
| In Vivo | The pharmacokinetic parameters of Agelastatin A(1a) a single 2.5 mg/kg dose in mice[2]. Parameter/td> intravenous (IV) intraperitoneal (IP) ACU 1742 2946 Cmax 4.5 μM 1.65 μM Tmax 2 min 30 min t1/2 4 min 1 h |
| References |
| Density | 2.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 760.7±60.0 °C at 760 mmHg |
| Molecular Formula | C12H13BrN4O3 |
| Molecular Weight | 341.16100 |
| Flash Point | 413.9±32.9 °C |
| Exact Mass | 340.01700 |
| PSA | 86.60000 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.929 |
| (5aS,5bS,8aS,9aR)-1-Bromo-8a-hydroxy-8-methyl-5,5a,5b,6,8,8a,9,9a-octahydroimidazo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazine-4,7-dione |
| agelastatin A |
| Imidazo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazine-4,7-dione, 1-bromo-5,5a,5b,6,8,8a,9,9a-octahydro-8a-hydroxy-8-methyl-, (5aS,5bS,8aS,9aR)- |