55038-27-2

55038-27-2 structure

Name: Sarcophine
Chemical Name: Sarcophine
CAS Number: 55038-27-2
Molecular Formula: C₂₀H₂₈O₃
Molecular Weight: 316.43500
Catalog: Research Areas Neurological Disease
Create Date: 2017-04-17 18:09:38
Modify Date: 2024-01-13 15:47:01
Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC50 value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum[1].

Name	Sarcophine
Synonyms	Oxireno(9,10)cyclotetradeca(1,2-B)furan-9(1ah)-one,2,3,6,7,10A,13,14,14A-octahydro-1A,5,8,12-tetramethyl-(van) (9ci) (1aS,4E,10aS,11E,14aS)-2,3,6,7,10a,13,14,14a-Octahydro-1a,5,8,12-tetramethyloxireno[9,10]cyclotetradeca[1,2-b]furan-9(1aH)-one Sarcophyne Sarcophin Oxireno(9,10)cyclotetradeca(1,2-B)furan-9(1ah)-one,2,3,6,7,10A,13,14,14A-octahydro-1A,5,8,12-tetramethyl-,(1as-(1ar,4E,10ar,11E,14ar*)) Sarcophin a

Description	Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC50 value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum[1].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Sarcophine ((+)-Sarcophine) 是一种重组甘氨酸受体抑制剂，Ki 值为 2.1 μM[1]。 Sarcophine (1-100 mM; 24 h) 对 HEK293 细胞具有细胞毒性，LD50 值为 29.3 mM[1]。
References	[1]. Saleh HA, et, al. Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors. Neurotoxicology. 2020 Sep;80:105-111.

CHEMICAL NAME :: Oxireno(9,10)cyclotetradeca(1,2-b)furan-9(1ah)-one, 2,3,6,7,10a,13,14,14a-octahydro- 1a,5,8,12-tetramethyl-, (1aS-(1aR*,4E,10aR*,11E,14aR*))-

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 12,593,1974

65817-46-1

~82%

55038-27-2

Literature: Frincke, James M.; McIntyre, Douglas E.; Faulkner, John D. Tetrahedron Letters, 1980 , vol. 21, p. 735 - 738

65817-46-1

74740-97-9

55038-27-2

137762-26-6

Detail

Literature: Kobayashi, Masaru Journal of Chemical Research, Miniprint, 1991 , # 11 p. 2840 - 2852