1260173-94-1
1260173-94-1 structure
- Name: L-threo-(3,4-dihydroxyphenyl)serine hydrochloride
- Chemical Name: L-threo-(3,4-dihydroxyphenyl)serine hydrochloride
- CAS Number: 1260173-94-1
- Molecular Formula: C9H12ClNO5
- Molecular Weight: 249.64800
- Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
- Create Date: 2018-02-05 16:16:23
- Modify Date: 2023-01-11 19:24:25
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Droxidopa (L-DOPS) hydrochloride is a potent, orally active norepinephrine precursor. Droxidopa hydrochloride increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa hydrochloride has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder)[1][2][3][4].
| Name | L-threo-(3,4-dihydroxyphenyl)serine hydrochloride |
|---|---|
| Synonyms | threo-3-(3,4-dihydroxyphenyl)-L-serine hydrochloride |
| Description | Droxidopa (L-DOPS) hydrochloride is a potent, orally active norepinephrine precursor. Droxidopa hydrochloride increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa hydrochloride has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder)[1][2][3][4]. |
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| Related Catalog | |
| In Vivo | Droxidopa hydrochloride (200 mg/kg;i.p.) alters dopamine neuron and prefrontal cortex activity and improves attention-deficit/hyperactivity disorder-like behaviors in rats[2].Droxidopa hydrochloride (10, 20 mg/kg; i.p.) significantly increases the paw withdrawal latency and inhibits mechanical hypersensitivity to thermal stimulation in 6-OHDA-lesioned rats at the 5th week after surgery[3]. Animal Model: 250-380g male Sprague-Dawley rats[2] Dosage: 200 mg/kg (10 mg/kg, i.p. benserazide was given to the animals at 20 or 30 min prior to L-DOPS injection) Administration: I.p. Result: Significantly decreased hyperactivity of BZ-pretreated SHR/NCrl at 30 (P < 0.01) and 40 min (P < 0.05) post-injection, improved inattention-like behavior of SHR/NCrl, and ameliorated impulsive-like behavior of SHR/NCrl and Wistar rats. |
| References |
[1]. Horacio Kaufmann, et al. Droxidopa for neurogenic orthostatic hypotension. Neurology, 2014; 83(4). |
| Molecular Formula | C9H12ClNO5 |
|---|---|
| Molecular Weight | 249.64800 |
| Exact Mass | 249.04000 |
| PSA | 124.01000 |
| LogP | 1.04540 |