114200-31-6

114200-31-6 structure

Name: PAOPA
Chemical Name: 2-oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1-pyrrolidineacetamide
CAS Number: 114200-31-6
Molecular Formula: C₁₁H₁₈N₄O₃
Molecular Weight: 254.28600
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-04-07 11:06:36
Modify Date: 2024-01-10 15:31:15
PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists[1].

Name	2-oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1-pyrrolidineacetamide
Synonyms	PAOPA 3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide 3(R)-(N-L-prolylamino)-2-oxo-1-pyrrolidineacetamide

Description	PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor
In Vitro	PAOPA (10 μM; 1.5 h) 增加 D2/eYFP. 细胞中 GRK2 的纹状体、arrestin-3、磷酸化 ERK1 和 ERK2 的表达[1]。 PAOPA (10 μM; 48 h) 促进 D2/eYFP. 细胞中 D2 受体内化[1]。
In Vivo	PAOPA (1 mg/kg; i.p.; once daily for 45 d) in chronic administration induces increased expression of D2 receptor regulation and downstream molecules (including GRK2, arrestin-3, and extracellular receptor kinase ERK 1/2) in mice[1].