64887-70-3

64887-70-3 structure

Name: (Nle4)-α-MSH
Chemical Name: 4-L-Norleucine-alpha-Melanotropin
CAS Number: 64887-70-3
Molecular Formula: C₇₈H₁₁₁N₂₁O₁₉
Molecular Weight: 1646.845
Catalog: Research Areas Others
Create Date: 2018-12-28 16:02:46
Modify Date: 2024-02-14 23:59:55
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment[1].

Name	4-L-Norleucine-alpha-Melanotropin
Synonyms	L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl- (4-Norleucine)Alpha-Msh 4-Nle-Alpha-Msh N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide Msh, 4-Nle-Alpha- N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-N-(diaminomethylidene)-L-ornithyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide

Description	(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
Target	tyrosinase; melanoma adenylate cyclase[1]
In Vitro	(Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity[1]. (Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells (NCTC 3960)[1]. (Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicating darkening response of frog skins[1]. (Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase[1].