1353550-13-6

1353550-13-6 structure

Name: Olmutinib
Chemical Name: N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide
CAS Number: 1353550-13-6
Molecular Formula: C₂₆H₂₆N₆O₂S
Molecular Weight: 486.589
Catalog: Research Areas Cancer
Create Date: 2018-09-05 22:21:02
Modify Date: 2025-08-21 00:55:45
Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.

Name	N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide
Synonyms	N-{3-[(2-{[4-(4-Methyl-1-piperazinyl)phenyl]amino}thieno[3,2-d]pyrimidin-4-yl)oxy]phenyl}acrylamide 2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]- Olmutinib N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino) thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide HM71224

Description	Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.
Related Catalog	Research Areas >> Cancer
Target	EGFRExon 19 deletion:9.2 nM (IC50, Cell Assay) EGFRL858R/T790M:10 nM (IC50, Cell Assay)
In Vitro	Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1].
References	[1]. Kim ES, et al. Olmutinib: First Global Approval. Drugs.?2016 Jul;76(11):1153-7.