- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Olmutinib
- Price: ￥4386.0/250mg ￥1756.0/50mg ￥2726.0/100mg ￥786.0/10mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: HM-61713 (BI-1482694)
- Price: $380.0/100mg $650.0/250mg $1100.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Olmutinib
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
1353550-13-6
1353550-13-6 structure
- Name: Olmutinib
- Chemical Name: N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide
- CAS Number: 1353550-13-6
- Molecular Formula: C26H26N6O2S
- Molecular Weight: 486.589
- Catalog: Research Areas Cancer
- Create Date: 2018-09-05 22:21:02
- Modify Date: 2024-01-07 19:50:31
-
Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.
| Name | N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide |
|---|---|
| Synonyms |
N-{3-[(2-{[4-(4-Methyl-1-piperazinyl)phenyl]amino}thieno[3,2-d]pyrimidin-4-yl)oxy]phenyl}acrylamide
2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]- Olmutinib N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino) thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide HM71224 |
| Description | Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. |
|---|---|
| Related Catalog | |
| Target |
EGFRExon 19 deletion:9.2 nM (IC50, Cell Assay) EGFRL858R/T790M:10 nM (IC50, Cell Assay) |
| In Vitro | Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1]. |
| References |
[1]. Kim ES, et al. Olmutinib: First Global Approval. Drugs.?2016 Jul;76(11):1153-7. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H26N6O2S |
| Molecular Weight | 486.589 |
| Exact Mass | 486.183807 |
| PSA | 110.86000 |
| LogP | 4.95 |
| Index of Refraction | 1.706 |
| Storage condition | -20℃ |