Olmutinib
Modify Date: 2025-08-21 00:55:45
Olmutinib structure
|
Common Name | Olmutinib | ||
|---|---|---|---|---|
| CAS Number | 1353550-13-6 | Molecular Weight | 486.589 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H26N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OlmutinibOlmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. |
| Name | N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide |
|---|---|
| Synonym | More Synonyms |
| Description | Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. |
|---|---|
| Related Catalog | |
| Target |
EGFRExon 19 deletion:9.2 nM (IC50, Cell Assay) EGFRL858R/T790M:10 nM (IC50, Cell Assay) |
| In Vitro | Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1]. |
| References |
[1]. Kim ES, et al. Olmutinib: First Global Approval. Drugs.?2016 Jul;76(11):1153-7. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H26N6O2S |
| Molecular Weight | 486.589 |
| Exact Mass | 486.183807 |
| PSA | 110.86000 |
| LogP | 4.95 |
| Index of Refraction | 1.706 |
| Storage condition | -20℃ |
| N-{3-[(2-{[4-(4-Methyl-1-piperazinyl)phenyl]amino}thieno[3,2-d]pyrimidin-4-yl)oxy]phenyl}acrylamide |
| 2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]- |
| Olmutinib |
| N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino) thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide |
| HM71224 |
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