9012-25-3

9012-25-3 structure

Name: catechol o-methyltransferase
Chemical Name: Catechol O-methyltransferases
CAS Number: 9012-25-3
Molecular Formula: C₃₈H₆₈O₇
Molecular Weight: 636.942
Catalog: Biochemical Amino acids and their derivatives Methionine derivatives
Create Date: 2018-04-16 08:00:00
Modify Date: 2025-08-26 05:37:35
Catechol O-methyltransferase (COMT) the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain[1].

Name	Catechol O-methyltransferases
Synonyms	MFCD00081488 2(5H)-Furanone, 3-[13-[5'-(1,5-dihydroxyundecyl)octahydro[2,2'-bifuran]-5-yl]-13-hydroxy-3-methyltridecyl]-5-methyl- EINECS 232-727-6 3-{13-[5'-(1,5-Dihydroxyundecyl)octahydro-2,2'-bifuran-5-yl]-13-hydroxy-3-methyltridecyl}-5-methyl-2(5H)-furanone

Description	Catechol O-methyltransferase (COMT) the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Du X, et, al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14609-14.

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