100403-19-8

100403-19-8 structure

Name: Ceramides Mixture
Chemical Name: Ceramides
CAS Number: 100403-19-8
Molecular Formula: C₂₄H₄₇NO₃
Molecular Weight: 397.63488
Catalog: Organic raw materials Amino compound Amide compound
Create Date: 2018-03-24 08:00:00
Modify Date: 2024-01-02 11:47:13
Ceramides Mixture is an endogenous ceramide and consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides Mixture is a main lipid component of the permeability barrier in epidermis. Ceramides Mixture is involved in the regulation of growth inhibition, cell cycle arrest, and modulation of telomerase activity[1][2].

Name	Ceramides
Synonyms	ceramide 1 ceramide 1 a caproyl sphingosine EINECS 309-560-3 ceramide 5 ceramide 6 ii ceramide 4 ceramide 3 ceramide 2

Description	Ceramides Mixture is an endogenous ceramide and consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides Mixture is a main lipid component of the permeability barrier in epidermis. Ceramides Mixture is involved in the regulation of growth inhibition, cell cycle arrest, and modulation of telomerase activity[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Cell Cycle/DNA Damage >> Telomerase Research Areas >> Metabolic Disease
In Vitro	Endogenous Ceramides (generated in response to bacterial sphingomyelinase overexpression or daunorubicin treatment) inhibits mRNA synthesis of telomerase reverse transcriptase and telomerase activity via inactivation of c-Myc transcription factor in the A549 human lung adenocarcinoma cell line[1]. The sustained generation of long chain endogenous ceramide requires the biochemical recycling of the sphingosine backbone of C6-ceramide, which involves deacylation and reacylation of ceramide for the generation of endogenous long chain ceramide (mainly C16:0- and C24:1-Ceramides), most likely by CoA-dependent ceramide synthase, which is inhibited by fumonisin B1. In A549 cells the generation of long chain endogenous ceramide mediates the effects of exogenous C6-ceramide on growth inhibition, cell cycle arrest, and the modulation of telomerase activity[1].
References	[1]. Ogretmen B, et al. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem. 2002 Apr 12;277(15):12960-9. [2]. Macheleidt O, et al. Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. J Invest Dermatol. 2002 Jul;119(1):166-73.

Molecular Formula	C₂₄H₄₇NO₃
Molecular Weight	397.63488
Storage condition	-20°C

Hazard Codes	Xi

100403-19-8	115112-73-7
13054-98-3	330988-72-2
25154-52-3	8011-63-0
473545-41-4	36804-17-8
101660-05-3	956595-89-4
1932233-01-6	1090893-04-1
1089635-80-2	211174-57-1
1135283-66-7	1424507-29-8
1090704-04-3	1111604-93-3
1147347-52-1	1293877-82-3