Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isopropyl adipate
Price: ￥118.0/5ml
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Diisopropyl adipate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Diisopropyl adipate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Diisopropyl adipate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

6938-94-9

6938-94-9 structure

Name: Isopropyl adipate
Chemical Name: Adipic Acid Diisopropyl Ester
CAS Number: 6938-94-9
Molecular Formula: C₁₂H₂₂O₄
Molecular Weight: 230.30
Catalog: Catalysts and additives Plastic rubber additive
Create Date: 2018-04-20 08:00:00
Modify Date: 2024-01-02 16:44:48
Diisopropyl adipate is an alternative plasticizer and a TRPA1 activator. Diisopropyl adipate activates TRPA1 and enhances FITC-induced contact hypersensitivity (CHS).Diisopropyl adipate also serves as an ingredient in cosmetics and drug formulations topically applied to the skin. Diisopropyl adipate can be used as an excipient, such as emollients, plasticizers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

Name	Adipic Acid Diisopropyl Ester
Synonyms	Hexanedioic acid, bis(1-methylethyl) ester MFCD00026391 Diisopropyl adipate bis(1-methylethyl) hexanedioate Adipic acid diisopropyl ester Adipic acid isopropyl ester Adipic acid, diisopropyl ester Diisopropyl hexanedioate Isopropyl adipate EINECS 230-072-0

Description	Diisopropyl adipate is an alternative plasticizer and a TRPA1 activator. Diisopropyl adipate activates TRPA1 and enhances FITC-induced contact hypersensitivity (CHS).Diisopropyl adipate also serves as an ingredient in cosmetics and drug formulations topically applied to the skin. Diisopropyl adipate can be used as an excipient, such as emollients, plasticizers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Others
References	[1]. Kurohane K, et al. Adjuvant Effect of an Alternative Plasticizer, Diisopropyl Adipate, on a Contact Hypersensitivity Mouse Model: Link with Sensory Ion Channel TRPA1 Activation. Biol Pharm Bull. 2015;38(7):1054-62. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Density	1.0±0.1 g/cm3
Boiling Point	252.6±8.0 °C at 760 mmHg
Melting Point	-1 °C
Molecular Formula	C₁₂H₂₂O₄
Molecular Weight	230.30
Flash Point	109.8±16.9 °C
Exact Mass	230.151810
PSA	52.60000
LogP	2.79
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.435

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AV1575000

CHEMICAL NAME :: Adipic acid, diisopropyl ester

CAS REGISTRY NUMBER :: 6938-94-9

BEILSTEIN REFERENCE NO. :: 1785346

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H22-O4

MOLECULAR WEIGHT :: 230.34

WISWESSER LINE NOTATION :: 1Y1&OV4VOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 3(3),101,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MRLR** U.S. Army, Chemical Corps Medical Laboratories Research Reports. (Army Chemical Center, Edgewood Arsenal, MD) Volume(issue)/page/year: #256,1954 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1241 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1288 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1241 No. of Facilities: 423 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 4112 (estimated) No. of Female Employees: 2909 (estimated)

Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RTECS	AV1575000
HS Code	2917120090

67-63-0

518068-80-9

~86%

6938-94-9

Literature: Lee, Jong Chan; Ku, Chang Hoe Synlett, 2002 , # 10 p. 1679 - 1680

4883-67-4

67-63-0

~71%

6938-94-9

Literature: Ballini, Roberto; Bosica, Giovanna Tetrahedron, 1997 , vol. 53, # 47 p. 16131 - 16138

124-04-9

67-63-0

~89%

6938-94-9

Literature: Kazemi, Foad; Kiasat, Ali Reza; Mombaini, Began Phosphorus, Sulfur and Silicon and the Related Elements, 2004 , vol. 179, # 6 p. 1187 - 1191

124-04-9

~67%

6938-94-9

Literature: Parmar, Anupama; Kaur, Jatinder; Goyal, Rita; Kumar, Baldev; Kumar, Harish Synthetic Communications, 1998 , vol. 28, # 15 p. 2821 - 2826

Precursor 4
67-63-0 518068-80-9 4883-67-4 124-04-9
DownStream 2
97159-24-5 105-02-2

HS Code	2917120090
Summary	2917120090. adipic acid and its salts. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

6938-94-9	121879-14-9
121803-76-7	94160-29-9
4399-86-4	51265-84-0
230309-38-3	924-83-4
51265-85-1	5129-42-0