127476-26-0

127476-26-0 structure

Name: Conantokin-T
Chemical Name: Conantokin-T
CAS Number: 127476-26-0
Molecular Formula: C₁₁₀H₁₇₅N₃₁O₄₅S
Molecular Weight: 2683.81000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-01-23 01:08:06
Modify Date: 2025-11-10 16:46:30
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa[1].

Name	Conantokin-T
Synonyms	Conatokin t

Description	Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	IC50: 2 μM (NMDA)[1]
In Vitro	Conantokin-T produces a partial antagonism of NMDA receptor function with an IC50 value of 2 μM[1].
In Vivo	Conantokin-T induces sleep-like symptoms in young mice[1].