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36376-47-3

36376-47-3 structure
36376-47-3 structure
  • Name: 4-Methylhistamine dihydrochloride
  • Chemical Name: 2-(5-methyl-1H-imidazol-4-yl)ethanamine,dihydrochloride
  • CAS Number: 36376-47-3
  • Molecular Formula: C6H13Cl2N3
  • Molecular Weight: 198.09400
  • Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
  • Create Date: 2018-06-11 07:47:36
  • Modify Date: 2025-08-25 18:26:09
  • 4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1].
Name 2-(5-methyl-1H-imidazol-4-yl)ethanamine,dihydrochloride
Synonyms 2-<5-methyl-1H-imidazol-4-yl>ethanamine dihydrochloride
5-metilistamina diclorinato
5-Methylhistamine dihydrochloride
5-Methyl-1H-imidazole-4-ethanamine dihydrochloride
2-methylhistamine dihydrochloride
5-metilistamina dicloridrato
4-Methylhistamine dihydrochloride
Description 4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1].
Related Catalog
Target

histamine 4 receptor[1]

References

[1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349.
Density 1.1g/cm3
Boiling Point 345ºC at 760 mmHg
Molecular Formula C6H13Cl2N3
Molecular Weight 198.09400
Flash Point 189.3ºC
Exact Mass 197.04900
PSA 54.70000
LogP 2.52360
Index of Refraction 1.558
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI3505800
CHEMICAL NAME :
Imidazole, 4-(2-aminoethyl)-5-methyl-, dihydrochloride
CAS REGISTRY NUMBER :
36376-47-3
LAST UPDATED :
199206
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H11-N3.2Cl-H
MOLECULAR WEIGHT :
198.12
WISWESSER LINE NOTATION :
T5M CNJ D2Z E1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
991 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - pleural effusion
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
198 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943
Hazard Codes Xi
HS Code 2933290090
HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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