Shanghai Nianxing Industrial Co., Ltd
China
Product Name: POBN
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: POBN
Price: ￥5808.0/5g ￥2308.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: POBN
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

66893-81-0

66893-81-0 structure

66893-81-0 structure

Name: POBN
Chemical Name: tert-butyl-[(1-oxidopyridin-4-ylidene)methyl]-oxoazanium
CAS Number: 66893-81-0
Molecular Formula: C₁₀H₁₄N₂O₂
Molecular Weight: 194.230
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-12-19 19:46:26
Modify Date: 2025-08-20 07:46:39
POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts[1].

Name	tert-butyl-[(1-oxidopyridin-4-ylidene)methyl]-oxoazanium
Synonyms	N-(4-Pyridylmethylene)-tert-butylamine N,N'-dioxide MFCD00041022 4-{[(2-Methyl-2-propanyl)(oxo)ammonio]methylene}-1(4H)-pyridinolate 4-{[tert-butyl(oxo)ammonio]methylidene}pyridin-1(4h)-olate 2-methyl-N-(4-pyridinemethylidene)propan-2-amine N,N'-dioxide N-(4-pyridylmethylene)-t-butylamine N,N'-dioxide N,N'-Dioxide-2-methyl-N-(4-pyridinylmethylene)-2-propanamine 2-Propanaminium, N-[(1-hydroxy-4(1H)-pyridinylidene)methyl]-2-methyl-N-oxo-, inner salt POBN EINECS 266-512-3

Description	POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	When POBN (20 mM) and Sodium formate (100 mM) are mixed in the collecting tube with bile in the presence of 2,2′-dipyridyl (DP) (5 mM) and bathocuproinedisulfonic acid disodium salt hydrate (BC) (5 mM), only a minor residual signal of POBN radical adduct is observed[1].
In Vivo	Electron spin resonance (ESR) spectrum of radical adducts detected in bile of rats 1 h after acute Sodium formate (2 g/kg) and POBN (1.5 g/kg) i.p. administration[1]. Animal Model: Fischer male rats (300-400 g)[1] Dosage: 1.5 g/kg (Pharmacokinetic Analysis) Administration: Injected simultaneously i.p. Result: A strong six-line ESR signal of the POBN radical adduct was detected in the bile of rats after acute sodium formate poisoning.
References	[1]. A E Dikalova, et al. An in vivo ESR spin-trapping study: free radical generation in rats from formate intoxication--role of the Fenton reaction. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13549-53.

Density	1.056g/cm3
Boiling Point	409.104ºC at 760 mmHg
Melting Point	183-185ºC(lit.)
Molecular Formula	C₁₀H₁₄N₂O₂
Molecular Weight	194.230
Flash Point	201.219ºC
Exact Mass	194.105530
PSA	54.21000
LogP	2.36600
Index of Refraction	1.517
Storage condition	2-8°C
Water Solubility	water: soluble10mg/mL, clear, colorless to faintly yellow

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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