POBN

Modify Date: 2025-08-20 07:46:39

POBN Structure
POBN structure
Common Name POBN
CAS Number 66893-81-0 Molecular Weight 194.230
Density 1.056g/cm3 Boiling Point 409.104ºC at 760 mmHg
Molecular Formula C10H14N2O2 Melting Point 183-185ºC(lit.)
MSDS Chinese USA Flash Point 201.219ºC

 Use of POBN


POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts[1].

 Names

Name tert-butyl-[(1-oxidopyridin-4-ylidene)methyl]-oxoazanium
Synonym More Synonyms

 POBN Biological Activity

Description POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts[1].
Related Catalog
In Vitro When POBN (20 mM) and Sodium formate (100 mM) are mixed in the collecting tube with bile in the presence of 2,2′-dipyridyl (DP) (5 mM) and bathocuproinedisulfonic acid disodium salt hydrate (BC) (5 mM), only a minor residual signal of POBN radical adduct is observed[1].
In Vivo Electron spin resonance (ESR) spectrum of radical adducts detected in bile of rats 1 h after acute Sodium formate (2 g/kg) and POBN (1.5 g/kg) i.p. administration[1]. Animal Model: Fischer male rats (300-400 g)[1] Dosage: 1.5 g/kg (Pharmacokinetic Analysis) Administration: Injected simultaneously i.p. Result: A strong six-line ESR signal of the POBN radical adduct was detected in the bile of rats after acute sodium formate poisoning.
References

[1]. A E Dikalova, et al. An in vivo ESR spin-trapping study: free radical generation in rats from formate intoxication--role of the Fenton reaction. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13549-53.

 Chemical & Physical Properties

Density 1.056g/cm3
Boiling Point 409.104ºC at 760 mmHg
Melting Point 183-185ºC(lit.)
Molecular Formula C10H14N2O2
Molecular Weight 194.230
Flash Point 201.219ºC
Exact Mass 194.105530
PSA 54.21000
LogP 2.36600
Index of Refraction 1.517
Storage condition 2-8°C
Water Solubility water: soluble10mg/mL, clear, colorless to faintly yellow

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles8

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 Synonyms

N-(4-Pyridylmethylene)-tert-butylamine N,N'-dioxide
MFCD00041022
4-{[(2-Methyl-2-propanyl)(oxo)ammonio]methylene}-1(4H)-pyridinolate
4-{[tert-butyl(oxo)ammonio]methylidene}pyridin-1(4h)-olate
2-methyl-N-(4-pyridinemethylidene)propan-2-amine N,N'-dioxide
N-(4-pyridylmethylene)-t-butylamine N,N'-dioxide
N,N'-Dioxide-2-methyl-N-(4-pyridinylmethylene)-2-propanamine
2-Propanaminium, N-[(1-hydroxy-4(1H)-pyridinylidene)methyl]-2-methyl-N-oxo-, inner salt
POBN
EINECS 266-512-3
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Price: ¥350/10 mg

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