5560-59-8
5560-59-8 structure
- Name: Alverine citrate
- Chemical Name: alverine citrate
- CAS Number: 5560-59-8
- Molecular Formula: C26H35NO7
- Molecular Weight: 473.55900
- Catalog: Organic raw materials Amino compound Acyclic monoamines, polyamines and their derivatives and salts
- Create Date: 2018-04-10 08:00:00
- Modify Date: 2025-08-22 08:04:10
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Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.
| Name | alverine citrate |
|---|---|
| Synonyms |
N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine,2-hydroxypropane-1,2,3-tricarboxylic acid
MFCD00035086 EINECS 226-929-3 Alverine Citrate Alverine (citrate) |
| Description | Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. |
|---|---|
| Related Catalog | |
| Target |
5-HT1A Receptor:101 nM (IC50) |
| In Vitro | Alverine is a drug used for functional gastrointestinal disorders. Alverine acts directly on the muscle in the gut, causing it to relax. Alverine Citrate (20 mg/kg) suppresses the effect of 5-HTP, but not that of 8-OH-DPAT. However, when injected intracerebroventricularly (75 μg/rat) alverine citrate reduces 8-OH-DPAT-induced enhancement of rectal distension-induced abdominal contractions. In-vitro binding studies reveal that Alverine citrate has a high affinity for 5-HT1A receptors and a weak affinity for 5-HT3 and 5-HT4 subtypes[1]. Alverine may increase Ca influx during action potentials due to inhibition of the inactivation of L-type Ca channels, but may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+[2]. |
| References |
| Boiling Point | 358.8ºC at 760mmHg |
|---|---|
| Molecular Formula | C26H35NO7 |
| Molecular Weight | 473.55900 |
| Flash Point | 174.4ºC |
| Exact Mass | 473.24100 |
| PSA | 135.37000 |
| LogP | 3.32540 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2921499090 |
| HS Code | 2921499090 |
|---|---|
| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |