Alverine citrate
Modify Date: 2025-08-22 08:04:10
Alverine citrate structure
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Common Name | Alverine citrate | ||
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| CAS Number | 5560-59-8 | Molecular Weight | 473.55900 | |
| Density | N/A | Boiling Point | 358.8ºC at 760mmHg | |
| Molecular Formula | C26H35NO7 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 174.4ºC | |
Use of Alverine citrateAlverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. |
| Name | alverine citrate |
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| Synonym | More Synonyms |
| Description | Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. |
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| Related Catalog | |
| Target |
5-HT1A Receptor:101 nM (IC50) |
| In Vitro | Alverine is a drug used for functional gastrointestinal disorders. Alverine acts directly on the muscle in the gut, causing it to relax. Alverine Citrate (20 mg/kg) suppresses the effect of 5-HTP, but not that of 8-OH-DPAT. However, when injected intracerebroventricularly (75 μg/rat) alverine citrate reduces 8-OH-DPAT-induced enhancement of rectal distension-induced abdominal contractions. In-vitro binding studies reveal that Alverine citrate has a high affinity for 5-HT1A receptors and a weak affinity for 5-HT3 and 5-HT4 subtypes[1]. Alverine may increase Ca influx during action potentials due to inhibition of the inactivation of L-type Ca channels, but may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+[2]. |
| References |
| Boiling Point | 358.8ºC at 760mmHg |
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| Molecular Formula | C26H35NO7 |
| Molecular Weight | 473.55900 |
| Flash Point | 174.4ºC |
| Exact Mass | 473.24100 |
| PSA | 135.37000 |
| LogP | 3.32540 |
| InChIKey | RYHCACJBKCOBTJ-UHFFFAOYSA-N |
| SMILES | CCN(CCCc1ccccc1)CCCc1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2921499090 |
| HS Code | 2921499090 |
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| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Validated LC-MS/MS method for determination of Alverine and one of its hydroxy metabolites in human plasma along with its application to a bioequivalence study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 197-206, (2009) The present research work involves a first of its kind rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method developed and validated for simultaneous analysis of Alverin... |
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A general practice study to compare alverine citrate with mebeverine hydrochloride in the treatment of irritable bowel syndrome.
Br. J. Clin. Pract. 40(7) , 276-8, (1986)
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Alverine citrate, simeticone, and Rome III irritable bowel syndrome.
Aliment. Pharmacol. Ther. 31(7) , 767-8; author reply 768-9, (2010)
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| N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine,2-hydroxypropane-1,2,3-tricarboxylic acid |
| MFCD00035086 |
| EINECS 226-929-3 |
| Alverine Citrate |
| Alverine (citrate) |