69563-88-8

69563-88-8 structure

Name: GI-530159
Chemical Name: 2,2-bis[4-(4-aminophenoxy)phenyl]hexafluoropropane
CAS Number: 69563-88-8
Molecular Formula: C₂₇H₂₀F₆N₂O₂
Molecular Weight: 518.450
Catalog: Organic raw materials Organic fluorine compound Fluoropropane series
Create Date: 2018-12-25 16:07:26
Modify Date: 2025-08-21 10:36:07
GI-530159 is a selective, mechanosensitive opener of TREK1 (K2P2.1) and TREK2 (K2P10.1) channels, with an EC50 of 0.76 μM for TREK1. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels. GI-530159 reduces rat dorsal root ganglion neuron excitability[1].

Name	2,2-bis[4-(4-aminophenoxy)phenyl]hexafluoropropane
Synonyms	2,2-bis(4-[4-aminophenoxy]phenyl)hexafluoropropane 2,2-bis[4-(p-aminophenoxy)phenyl]hexafluoropropane 4,4'-[(1,1,1,3,3,3-Hexafluoro-2,2-propanediyl)bis(4,1-phenyleneoxy)]dianiline 2,2-bis[4-(4'-aminophenoxy)phenyl]-1,1,1,3,3,3-hexafluoropropane Benzenamine, 4,4'-[[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis- 2,2-bis[4-(4-aminophenoxy)-phenyl]hexafluoropropane 4,4'-[(1,1,1,3,3,3-hexafluoropropane-2,2-diyl)bis(benzene-4,1-diyloxy)]dianiline HFBAPP MFCD00015723 [1,1-bis(trifluoromethyl)-1,1-bis(4-(4-amino-phenoxy)-phenyl)]methane 1,1,1,3,3,3-hexafluoro-2,2-bis[4-(4-aminophenoxy)phenyl]propane isbenzenamine 2,2'-BIS[4-(4-AMINOPHENOXY)PHENY]HEXAFLUOROPROPANE BAPOFP BIS-AF-A 4-BDAF leneoxy))bis 4',4'''-(Hexafluoroisopropylidene)-bis-(4-phenoxyaniline) 4,4'-[(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)bis(4,1-phenyleneoxy)]dianiline 2,2-BIS[4-(4-AMINOPH

Description	GI-530159 is a selective, mechanosensitive opener of TREK1 (K2P2.1) and TREK2 (K2P10.1) channels, with an EC50 of 0.76 μM for TREK1. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels. GI-530159 reduces rat dorsal root ganglion neuron excitability[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Loucif AJC, et al. GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability. Br J Pharmacol. 2018;175(12):2272-2283.

CHEMICAL NAME :: Benzenamine, 4,4'-((2,2,2-trifluoro-1-(trifluoromethyl)ethylidene) bis(4,1-phenyleneoxy) )bis-

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1 ** ACUTE TOXICITY DATA **

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CY1213000
HS Code	2922299090

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%