122752-21-0
122752-21-0 structure
- Name: Mycalolide B
- Chemical Name: mycalolide b
- CAS Number: 122752-21-0
- Molecular Formula: C52H74N4O17
- Molecular Weight: 1027.16000
- Catalog: Research Areas Others
- Create Date: 2016-02-20 18:09:46
- Modify Date: 2024-01-09 19:00:46
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Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1].
| Name | mycalolide b |
|---|---|
| Synonyms |
mycalolides B
4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C Mycalolide B,Mycale sp. |
| Description | Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1]. |
|---|---|
| Related Catalog | |
| Target |
actomyosin ATPase[1] |
| In Vitro | Mycalolide-B belongs to macrolide antibiotics and consists of tris-oxazole with strong cytotoxic activity (IC50: 10-50 nM for growth of L1210 murine leukemia cells). Mycalolide-B, a toxin isolated from marine sponge, inhibits smooth muscle contractions without changing cytosolic Ca2+ levels. Mycalolide-B also inhibits Ca2+-induced contraction in permeabilized smooth muscles. Mycalolide-B inhibits superprecipitation and Mg2+-ATPase activity stimulated by Ca2+ without changing myosin light chain phosphorylation. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1]. |
| References |
| Density | 1.23 g/cm3 |
|---|---|
| Boiling Point | 1042.3ºC at 760 mmHg |
| Molecular Formula | C52H74N4O17 |
| Molecular Weight | 1027.16000 |
| Flash Point | 584.2ºC |
| Exact Mass | 1026.50000 |
| PSA | 260.75000 |
| LogP | 7.39070 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.548 |
| Hazard Codes | Xi |
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