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1722-62-9

1722-62-9 structure
1722-62-9 structure
  • Name: Mepivacaine hydrochloride
  • Chemical Name: mepivacaine hydrochloride
  • CAS Number: 1722-62-9
  • Molecular Formula: C15H23ClN2O
  • Molecular Weight: 282.809
  • Catalog: API Anesthetic Agents Local anesthetics
  • Create Date: 2018-05-12 08:00:00
  • Modify Date: 2024-01-01 20:02:59
  • Mepivacaine is a tertiary amine used as a local anesthetic.Target: Sodium ChannelMepivacaine is a local anesthetic of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine). Mepivacaine is used in any infiltration and regional anesthesia. It is supplied as the hydrochloride salt of the racemate [1]. Mepivacaine displayed a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displayed a preference for TTXs Na(+) channels [2].
Name mepivacaine hydrochloride
Synonyms (±)-1-Methyl-2',6'-pipecoloxylidide monohydrochloride
Mepivacaine hydrochloride
Mepivastesin
N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide,hydrochloride
(±)-N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide Hydrochloride
Scandicain
1-Methyl-2',6'-pipecoloxylidide hydrochloride
Carbocaina
N-(2,6-diméthylphényl)-1-méthylpipéridine-2-carboxamide chlorhydrate
1-Methyl-2',6'-pipecoloxylidide monohydrochloride
N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide Hydrochloride
Mepivicaine hydrochloride
N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide hydrochloride
Mepivacaine HCL
N-(2,6-Dimethylphenyl)-1-methylpiperidin-2-carboxamidhydrochlorid
N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide hydrochloride (1:1)
N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride (1:1)
MFCD00243006
Carbocaine hydrochloride
Meaverin
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, hydrochloride (1:1)
EINECS 217-023-9
Mepivacaine (hydrochloride)
Description Mepivacaine is a tertiary amine used as a local anesthetic.Target: Sodium ChannelMepivacaine is a local anesthetic of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine). Mepivacaine is used in any infiltration and regional anesthesia. It is supplied as the hydrochloride salt of the racemate [1]. Mepivacaine displayed a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displayed a preference for TTXs Na(+) channels [2].
Related Catalog
References

[1]. Burm, A.G., et al., Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers. Anesth Analg, 1997. 84(1): p. 85-9.

[2]. Leffler, A., J. Reckzeh, and C. Nau, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol, 2010. 630(1-3): p. 19-28.
Boiling Point 383.1ºC at 760 mmHg
Melting Point 255-257ºC (dec.)
Molecular Formula C15H23ClN2O
Molecular Weight 282.809
Flash Point 185.5ºC
Exact Mass 282.149902
PSA 32.34000
LogP 3.53910
Vapour Pressure 4.52E-06mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TK6475000
CHEMICAL NAME :
2',6'-Pipecoloxylidide, 1-methyl -, monohydrochloride
CAS REGISTRY NUMBER :
1722-62-9
LAST UPDATED :
199701
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C15-H22-N2-O.Cl-H
MOLECULAR WEIGHT :
282.85
WISWESSER LINE NOTATION :
T6NTJ A1 BVMR C1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 40,592,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,295,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,295,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,69,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,295,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,69,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,69,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,295,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,295,1960 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
160 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 51,477,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1078 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 765 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1078 No. of Facilities: 428 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 4657 (estimated) No. of Female Employees: 2567 (estimated)
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR UN 2811 6.1 / PGIII
RTECS TK6475000
HS Code 2933399090
Precursor  0

DownStream  1

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 1722-62-9 | Chemsrc address: https://www.chemsrc.com/en/baike/1189830.html

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