1222878-02-5
1222878-02-5 structure
- Name: ML169
- Chemical Name: vu0405652
- CAS Number: 1222878-02-5
- Molecular Formula: C21H17BrFN3O4S
- Molecular Weight: 506.34
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2017-03-03 23:38:12
- Modify Date: 2025-08-25 17:41:20
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ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease[1].
| Name | vu0405652 |
|---|---|
| Synonyms | ml169 |
| Description | ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease[1]. |
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| Related Catalog | |
| Target |
EC50: 1.38 µM (M1 mAChR)[1] |
| In Vitro | ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M1–M5[1]. ML169 shifts APP processing towards a non-amyloidogenic pathway[1]. ML169 (2 µM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 µM CCh[1]. |
| In Vivo | ML169 (VU0405652) (10 mg/kg; i.p.) affords a brainAUC/plasmaAUC of 0.32 at 1 h in rats[1]. |
| References |
| Molecular Formula | C21H17BrFN3O4S |
|---|---|
| Molecular Weight | 506.34 |
| Exact Mass | 505.01100 |
| PSA | 102.58000 |
| LogP | 5.45380 |
| RIDADR | NONH for all modes of transport |
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