1342276-76-9

1342276-76-9 structure

Name: RKI-1313
Chemical Name: 1-(3-methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea
CAS Number: 1342276-76-9
Molecular Formula: C₁₇H₁₆N₄O₂S
Molecular Weight: 340.400
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2018-06-13 16:51:41
Modify Date: 2025-08-27 12:02:53
RKI-1313 is a ROCK inhibitor with IC50s of 34, 8 µM for ROCK 1 and ROCK 2, respectively. RKI-1313 shows little effect on the phosphorylation levels of ROCK substrates, migration, invasion or anchorage-independent growth[1].

Name	1-(3-methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea
Synonyms	1-(3-Methoxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea 1-(3-Methoxybenzyl)-3-[4-(4-pyridinyl)-1,3-thiazol-2-yl]urea Urea, N-[(3-methoxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- RKI-1313

Description	RKI-1313 is a ROCK inhibitor with IC50s of 34, 8 µM for ROCK 1 and ROCK 2, respectively. RKI-1313 shows little effect on the phosphorylation levels of ROCK substrates, migration, invasion or anchorage-independent growth[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	ROCK1:34 μM (IC50) ROCK2:8 μM (IC50)
References	[1]. Patel RA, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34.

Precursor 0
DownStream 1
1342278-01-6