- DC Chemicals Limited
- China
- Product Name: Nac amide
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Nanjing Peptide Biotech Ltd
- China
- Product Name: N-Acetyl-L-cysteine amide
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
38520-57-9
38520-57-9 structure
- Name: N-Acetylcysteine amide
- Chemical Name: (2R)-2-acetamido-3-sulfanylpropanamide
- CAS Number: 38520-57-9
- Molecular Formula: C5H10N2O2S
- Molecular Weight: 162.21000
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2017-11-27 14:24:23
- Modify Date: 2024-01-02 14:12:12
-
N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent.
| Name | (2R)-2-acetamido-3-sulfanylpropanamide |
|---|---|
| Synonyms |
Nac amide
acetylcysteinamide Acetylcysteine amide (R)- 2-(Acetylamino)-3-mercapto-Propanamide AD4 N-Acetyl-L-cysteinamide NACA acetylcysteinamide N-Acetyl-L-cysteine amide N-Acetylcysteine amide NACA N-Acetyl-L-cysteinamide |
| Description | N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent. |
|---|---|
| Related Catalog | |
| In Vitro | N-Acetylcysteine amide shows no obvious effect on the viability of H9c2 cells treated with doxorubicin (DOX) at < 1 mM, but causes significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide (750 μM) reduces the ROS levle and lipid peroxidation induced by DOX, and restores GSH/GSSG ratio and activities of antioxidant enzymes, such as catalase (CAT), gluthathione peroxidase (GPx), gluthathione reductase (GR)[1]. N-Acetylcysteine amide (1 mM) protects the human brain microvascular endothelial (HBMVEC) from methamphetamine (METH)- induced cell death[3]. |
| In Vivo | N-Acetylcysteine amide has increased CNS bioavailability. N-Acetylcysteine amide (150 mg/kg, i.p.) improves cortical sparing and functional outcome, reduces oxidative stress, improves mitochondrial bioenergetics, and maintains mitochondrial glutathione content following traumatic brain injury (TBI) in rats[2]. |
| Cell Assay | To choose a sublethal concentration of N-Acetylcysteine amide and N-acetylcysteine for the study on their ability to protect cells from doxorubicin (DOX)-induced toxicity, H9c2 cells are exposed with N-Acetylcysteine amide or N-acetylcysteine at 0.25 mM, 0.50 mM, 0.75 mM, 1 mM, 2 mM, 5 mM, 10 mM, and 20 mM for 24 h. Untreated cells are used as the control for each experiment[1]. |
| Animal Admin | Rats[2] In order to assess mitochondrial respiration and glutathione content following traumatic brain injury (TBI), rats are randomly divided into three groups (n = 5 animals/group). (I.) N-Acetylcysteine amide group receives multiple bolus IP injections of N-Acetylcysteine amide (150 mg/kg) immediately after 5 minutes and then every 6 hours up to 24 hrs post-injury. (II.) Vehicle group receives equivalent v/v saline at 5 minutes and every 6 hours (6, 12, 18, 24 hrs) up to 24 hrs post-injury. (III.) Sham injured group animals do not receive any drug treatment. At 25 hrs post-injury, all animals are euthanized and mitochondria are isolated from the ipsilateral cortical hemisphere (6 mm punch) to carry out measurements of mitochondrial respiration and glutathione content[2]. |
| References |
| Molecular Formula | C5H10N2O2S |
|---|---|
| Molecular Weight | 162.21000 |
| Exact Mass | 162.04600 |
| PSA | 115.47000 |
| LogP | 0.89620 |
| Storage condition | -20℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2930909090 |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |