Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 8-Aza-bicyclo[3.2.1]octan-3-ol HCl
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538-09-0

538-09-0 structure

538-09-0 structure

Name: 8-Aza-bicyclo[3.2.1]octan-3-ol HCl
Chemical Name: Nortropine
CAS Number: 538-09-0
Molecular Formula: C₇H₁₃NO
Molecular Weight: 122.164
Catalog: Research Areas Others
Create Date: 2018-04-04 08:00:00
Modify Date: 2024-01-10 20:24:12
Nortropine (Nortropenol), isolated from the total alkaloids of Convolvulus subhirsutus, is an intermediate in tropine breakdown and reactions leading to succinate[1].

Name	Nortropine
Synonyms	β-Phenylethyl alcohol b-Phenylethanol β-Phenylethanol 3a-Nortropanol 2-Hydroxyethylbenzene (3-endo)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (1:1) Phenylethyl alcohol (USP) endo-8-azabicyclo(3.2.1)octan-3-ol hydrochloride β-phenylethyl alcoho 8-Aza-bicyclo[3.2.1]octan-3-ol HCl b-pea Nortropin (2-Hydroxyethyl)benzene 8-Azabicyclo[3.2.1]octan-3-ol Tropigenin nortropenol phenylethanol β-Phenethyl alcohol b-Phenylethyl alcohol (3-endo)-8-Azabicyclo[3.2.1]octan-3-olato(2-) hydrochloride (1:1) endo-8-Azabicyclo[3.2.1]octan-3-ol nortropan-3endo-ol N-Demethyltropine PEA N-normethyltropine Benzeneethanol Phenyl Ethanol Q2R 3-hydroxy-nortropan NOR-TROPANOL 2-Phenylethanol b-Phenethanol 8-Azabicyclo[3.2.1]octan-3-ol, (3-endo), hydrochloride (1:1) b-Hydroxyethylbenzene β-PEA Tropigenine Phenethylalcohol Phenylethyl alcohol β-Hydroxyethylbenzene

Description	Nortropine (Nortropenol), isolated from the total alkaloids of Convolvulus subhirsutus, is an intermediate in tropine breakdown and reactions leading to succinate[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Bartholomew BA, et al. Atropine Metabolism by Pseudomonas sp. Strain AT3: Evidence for Nortropine as an Intermediate in Tropine Breakdown and Reactions Leading to Succinate. Appl Environ Microbiol. 1996 Sep;62(9):3245-50. [2]. A. M. Gapparov, et al. Alkaloids of Convolvulus subhirsutus from Uzbekistan. Chemistry of Natural Compounds. 2007. 43(3):291-292.

Density	1.0±0.1 g/cm3
Boiling Point	218.2±8.0 °C at 760 mmHg
Melting Point	108-110ºC
Molecular Formula	C₇H₁₃NO
Molecular Weight	122.164
Flash Point	102.2±0.0 °C
Exact Mass	122.073166
PSA	40.46000
LogP	1.36
Vapour Pressure	0.1±0.5 mmHg at 25°C
Index of Refraction	1.536

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD0700000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Nortropan-3-alpha-ol

CAS REGISTRY NUMBER :: 538-09-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H13-N-O

MOLECULAR WEIGHT :: 127.21

WISWESSER LINE NOTATION :: T56 A AMTJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,97,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,97,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

Hazard Codes	Xi
HS Code	2933990090

Precursor 8
1234788-77-2 120-29-6 143557-91-9 115522-42-4
115522-58-2 115522-57-1 115522-45-7 51-55-8
DownStream 4
143557-91-9 120-29-6 17812-41-8 86-13-5

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%