16910-32-0
16910-32-0 structure
- Name: Obtusifoliol
- Chemical Name: obtusifoliol
- CAS Number: 16910-32-0
- Molecular Formula: C30H50O
- Molecular Weight: 426.71700
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2016-07-01 20:27:10
- Modify Date: 2025-08-25 17:38:36
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Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively[1].
| Name | obtusifoliol |
|---|---|
| Synonyms |
4alpha,14alpha-Dimethyl-5alpha-ergosta-8,24(28)-dien-3beta-ol
(3S,4S,5S,10S,13R,14R,17R)-4,10,13,14-tetramethyl-17-[(2R)-6-methyl-5-methylideneheptan-2-yl]-1,2,3,4,5,6,7,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol 4alpha,14alpha-Dimethyl-24-methylene-5alpha-cholesta-8-en-3beta-ol EECD77B7-C927-4E6E-B634-DEDFB042A6B9 methylsterol Obtusifoliol |
| Description | Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Obtusifoliol (0.1-100 µM; 48 hours) inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis[1]. Cell Viability Assay[2] Cell Line: MCF-7; MDA-MB231 breast cancer cells Concentration: 0.1, 1, 10, 40, 80, and 100 µM Incubation Time: 48 hours Result: Inhibited MCF-7 and MDA-MB231 breast cancer cells proliferation. |
| References |
| Density | 0.98g/cm3 |
|---|---|
| Boiling Point | 501.3ºC at 760mmHg |
| Molecular Formula | C30H50O |
| Molecular Weight | 426.71700 |
| Flash Point | 221.9ºC |
| Exact Mass | 426.38600 |
| PSA | 20.23000 |
| LogP | 8.33500 |
| Vapour Pressure | 3.77E-12mmHg at 25°C |
| Index of Refraction | 1.525 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
|---|