Obtusifoliol

Modify Date: 2025-08-25 17:38:36

Obtusifoliol Structure
Obtusifoliol structure
 Common Name Obtusifoliol
CAS Number 16910-32-0 Molecular Weight 426.71700
Density 0.98g/cm3 Boiling Point 501.3ºC at 760mmHg
Molecular Formula C30H50O Melting Point N/A
MSDS N/A Flash Point 221.9ºC

 Use of Obtusifoliol


Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively[1].

 Names

Name obtusifoliol
Synonym More Synonyms

 Obtusifoliol Biological Activity

Description Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively[1].
Related Catalog
In Vitro Obtusifoliol (0.1-100 µM; 48 hours) inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis[1]. Cell Viability Assay[2] Cell Line: MCF-7; MDA-MB231 breast cancer cells Concentration: 0.1, 1, 10, 40, 80, and 100 µM Incubation Time: 48 hours Result: Inhibited MCF-7 and MDA-MB231 breast cancer cells proliferation.
References

[1]. Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43(33):10789-99.

[2]. Aghaei M, et al Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231). Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26.

 Chemical & Physical Properties

Density 0.98g/cm3
Boiling Point 501.3ºC at 760mmHg
Molecular Formula C30H50O
Molecular Weight 426.71700
Flash Point 221.9ºC
Exact Mass 426.38600
PSA 20.23000
LogP 8.33500
Vapour Pressure 3.77E-12mmHg at 25°C
Index of Refraction 1.525
Storage condition -20°C

 Safety Information

Hazard Codes Xn

 Synonyms

4alpha,14alpha-Dimethyl-5alpha-ergosta-8,24(28)-dien-3beta-ol
(3S,4S,5S,10S,13R,14R,17R)-4,10,13,14-tetramethyl-17-[(2R)-6-methyl-5-methylideneheptan-2-yl]-1,2,3,4,5,6,7,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol
4alpha,14alpha-Dimethyl-24-methylene-5alpha-cholesta-8-en-3beta-ol
EECD77B7-C927-4E6E-B634-DEDFB042A6B9
methylsterol
Obtusifoliol
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