DC Chemicals Limited
China
Product Name: Pipequaline
Price: $500.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pipequaline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

77472-98-1

77472-98-1 structure

77472-98-1 structure

Name: Pipequaline
Chemical Name: 2-phenyl-4-(2-piperidin-4-ylethyl)quinoline
CAS Number: 77472-98-1
Molecular Formula: C₂₂H₂₄N₂
Molecular Weight: 316.43900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-02-09 08:00:00
Modify Date: 2024-01-08 15:40:54
Pipequaline (PK 8165) is a non-selective GABAA receptor partial agonist with anxiolytic activity.

Name	2-phenyl-4-(2-piperidin-4-ylethyl)quinoline
Synonyms	Pipequalina Pipequalina [Spanish] Pipequalinum [Latin] Quinoline,2-phenyl-4-(2-(4-piperidinyl)ethyl) 2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline 2-phenyl-4-[2-(piperidin-4-yl)ethyl]quinoline Pipequalinum PK-8165 Pipequaline

Description	Pipequaline (PK 8165) is a non-selective GABAA receptor partial agonist with anxiolytic activity.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease
In Vitro	Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1].
In Vivo	Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3].
Animal Admin	Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3].
References	[1]. Essassi D, et al. Pipequaline transport from blood to brain and liver: role of plasma protein-bound drug. J Pharm Pharmacol. 1989 Sep;41(9):595-600. [2]. Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. [3]. File SE., et al. Sedative effects of PK 9084 and PK 8165, alone and in combination with chlordiazepoxide. Br J Pharmacol. 1983 May;79(1):219-23.

Density	1.078g/cm3
Boiling Point	489.2ºC at 760 mmHg
Molecular Formula	C₂₂H₂₄N₂
Molecular Weight	316.43900
Flash Point	249.7ºC
Exact Mass	316.19400
PSA	24.92000
LogP	5.16280
Index of Refraction	1.602
Storage condition	2-8℃