433967-28-3

433967-28-3 structure

Name: VU 0357121
Chemical Name: 4-Butoxy-N-(2,4-difluorophenyl)benzamide
CAS Number: 433967-28-3
Molecular Formula: C₁₇H₁₇F₂NO₂
Molecular Weight: 305.319
Catalog: Biochemical Inhibitor Neuronal Signaling GluR agonist
Create Date: 2018-12-27 12:47:17
Modify Date: 2024-01-21 14:08:27
VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.IC50 Value: 33 nM(EC50)Target: mGluR5in vitro: VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. in vivo:

Name	4-Butoxy-N-(2,4-difluorophenyl)benzamide
Synonyms	Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- 4-Butoxy-N-(2,4-difluorophenyl)benzamide 4-Butoxy-N-(2,4-difluorophenyl)-benzamide VU 0357121 cc-377 VU-0357121 VU0357121

Description	VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.IC50 Value: 33 nM(EC50)Target: mGluR5in vitro: VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. in vivo:
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Hammond, Alexis S.; Rodriguez, Alice L.; Townsend, Steven D. et al. Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chemical Neuroscience (2010), 1(10), 702-716.