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80-50-2

80-50-2 structure
80-50-2 structure
  • Name: Endovalpin
  • Chemical Name: anisotropine methylbromide
  • CAS Number: 80-50-2
  • Molecular Formula: C27H43NO9
  • Molecular Weight: 525.63200
  • Catalog: Biochemical Inhibitor Mitogen-activated protein kinase (MAPK) ERK inhibitor
  • Create Date: 2018-07-10 13:05:41
  • Modify Date: 2025-08-27 11:26:51
  • Anisotropine methobromide is an orally active anticholinergic muscarinic antagonist. Anisotropine methobromide can inhibit gastric acid secretion and is used as an adjunct to peptic ulcers[1].
Name anisotropine methylbromide
Synonyms octatropine methylbromide
Methoxy(benzene-2,4,6-d3)
Anisole-2,4,6-d3
1,3,5-trideuterio-2-methoxy-benzene
CHOLINE IODIDE 1-HYDROXY-α-PHENYLCYCLOPENTANEACETATE
2,4,6-Trideutero-anisol
anisotropine methobromide
2,4,6-Trideuterio-anisol
anisotropine methyl bromide
2,4,6-trideuterioanisole
Description Anisotropine methobromide is an orally active anticholinergic muscarinic antagonist. Anisotropine methobromide can inhibit gastric acid secretion and is used as an adjunct to peptic ulcers[1].
Related Catalog
In Vivo Anisotropine methobromide (intravenous injection, 0.5 μM and 0.1 mL, once) can block acetylcholine-induced vocalization, intestinal spasm and intestinal contractions in conscious or anesthetized dogs[1]. Animal Model: Dogs weighing 2.5 to 5.0 kg[1] Dosage: 0.5 μM, 0.1 mL Administration: Intravenous injection; once Result: Inhibited the acetylcholine-induced vocalization with maximum inhibition of 85.1% and the acetylcholine-induced intestinal spasm with maximum inhibition of 79%.
References

[1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20.
Melting Point 329ºC
Molecular Formula C27H43NO9
Molecular Weight 525.63200
Exact Mass 525.29400
PSA 174.31000
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YM3710000
CHEMICAL NAME :
1-alpha-H,5-alpha-H-Tropanium, 3-alpha-hydroxy-8-methyl-, bromide, 2-propylvalerate
CAS REGISTRY NUMBER :
80-50-2
LAST UPDATED :
199504
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C17-H32-N-O2.Br
MOLECULAR WEIGHT :
362.41
WISWESSER LINE NOTATION :
T56 A AKTJ A1 A1 GOVY3&3 &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
705 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
129 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
133 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2759 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 197 (estimated) No. of Female Employees: 59 (estimated)
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H312-H332-H400
Precautionary Statements P273-P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;N: Dangerous for the environment;
Risk Phrases R20/21/22
Safety Phrases 36-61-60
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS YM3710000
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