26473-08-5

26473-08-5 structure

Name: 1,4-(2H6)Naphthalenedione
Chemical Name: 1,4-naphthoquinone-d6
CAS Number: 26473-08-5
Molecular Formula: C₁₀D₆O₂
Molecular Weight: 164.190
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2018-07-25 17:47:37
Modify Date: 2024-01-12 01:04:11
1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

Name	1,4-naphthoquinone-d6
Synonyms	Hexadeuterio-1,4-naphthoquinone 2.3-dicyano-1,4-naphtho-quinone 2,3-dicyano-1,4-napthoquinone 2,3-dicyanonaphtho-1,4-quinone Hexadeuteronaphtha-1,4-chinon 1,4-dioxo-1,4-dihydronaphthalene-2,3-dicarbonitrile 1,4<D6>-Naphthochinon (H)Naphthalene-1,4-dione 1,4-(H)Naphthalenedione 1,4-Naphthalenedione-d 1,4-naphthoquinone-2,3-dicarbonitrile <D6>-1,4-Naphthochinon

Description	1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Coelho-Cerqueira E, et al. Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase. Chem Biol Drug Des. 2014 Apr;83(4):401-10.

1146-65-2

78832-61-8

26473-08-5

Precursor 1
1146-65-2
DownStream 0