78832-61-8

78832-61-8 structure

78832-61-8 structure

Name: 2-naphthol-d8
Chemical Name: 2-naphthol-d8
CAS Number: 78832-61-8
Molecular Formula: C₁₀D₈O
Molecular Weight: 152.21900
Catalog: Research Areas Others
Create Date: 2018-09-17 17:21:12
Modify Date: 2024-01-02 19:22:13
2-Naphthol-d8 is the deuterium labeled 2-Naphthol[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2)[2].

Name	2-naphthol-d8
Synonyms	8-azabicyclo<5.4.0>undec-1(7)-en-9-one 1,3,4,5,6,7,8,O-octadeuterio-naphthalen-2-ol 1,2,3,4,5,6,7,8-Octahydrocyclohepta[b]pyrid-2-one 1,3,4,5,6,7,8,9-octahydro-cyclohepta[b]pyridin-2-one 2H-Cyclohepta[b]pyridin-2-one,1,3,4,5,6,7,8,9-octahydro 2-Oxo-1,2,3,4-tetrahydrocycloheptano<e>pyridin

Description	2-Naphthol-d8 is the deuterium labeled 2-Naphthol[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2)[2].
Related Catalog	Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Kapuci M, et al. Determination of cytotoxic and genotoxic effects of naphthalene, 1-naphthol and 2-naphthol on human lymphocyte culture. Toxicol Ind Health. 2014 Feb;30(1):82-9.

Molecular Formula	C₁₀D₈O
Molecular Weight	152.21900
Exact Mass	152.10800
PSA	20.23000
LogP	2.54540

1146-65-2 structure

1146-65-2

~%

78832-61-8 structure

78832-61-8

26473-08-5 structure

26473-08-5

Literature: Barkanova; Kaliya; Luk'yanets Mendeleev Communications, 2001 , vol. 11, # 3 p. 116 - 118

Precursor 1
1146-65-2
DownStream 0