Name | phleomycin from strepomyces verticillus |
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Synonyms |
PHLEOMYCIN
MFCD00131846 phleomycincomplex PHLEOMYCIN (STREPTOMYCES VERTICILLUS) phleomycin from streptomyces*verticillus ZEOCIN(TM) |
Description | Phleomycin is a wide-spectrum glycopeptide antibiotic found in Streptomyces verticillus. Phleomycin, an effective DNA-cleaving agent, binds and intercalates DNA to damage the integrity of the double helix, which is similar to Bleomycin (HY-17565A)[1]. |
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Related Catalog | |
Target |
IC50: Antibiotic[1] |
References |
Density | 1.83 g/cm3 |
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Boiling Point | 1718.8ºC at 760 mmHg |
Molecular Formula | C52H75N16O21S2 |
Molecular Weight | 1324.38000 |
Flash Point | 993.3ºC |
Exact Mass | 1323.47000 |
PSA | 664.89000 |
Appearance | light blue |
Vapour Pressure | 0mmHg at 25°C |
Index of Refraction | 1.777 |
Storage condition | 2-8°C |
Water Solubility | H2O: 10 mg/mL, clear, blue |
Synonym:Phleomycin Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 22 40 42/43 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Harmful if swallowed. Limited evidence of a carcinogenic effect. May cause sensitization by inhalation and skin contact.The toxicological properties of this material have not been fully investigated.Mutagen. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Skin contact may cause an allergic skin reaction (sensitization) in a small proportion of individuals. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May cause dyspnea (difficult or labored breathing). May cause respiratory sensitization. Chronic: Laboratory experiments have resulted in mutagenic effects. Section 4 - FIRST AID MEASURES Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 11006-33-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: blue Odor: odorless pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Soluble. Specific Gravity/Density: Molecular Formula: C13H28N3O12 Molecular Weight: 418.21 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 11006-33-0: SY0525000 LD50/LC50: CAS# 11006-33-0: Oral, mouse: LD50 = 371 mg/kg; Oral, rat: LD50 = 649 mg/kg. Carcinogenicity: Zeocin - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. R 40 Limited evidence of a carcinogenic effect. R 42/43 May cause sensitization by inhalation and skin contact. Safety Phrases: S 22 Do not breathe dust. S 36/37 Wear suitable protective clothing and gloves. WGK (Water Danger/Protection) CAS# 11006-33-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 11006-33-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 11006-33-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn: Harmful;Xi: Irritant; |
Risk Phrases | R22 |
Safety Phrases | 26-36 |
RIDADR | UN 2811 |
WGK Germany | 3 |
RTECS | SY0525000 |
Packaging Group | III |
Hazard Class | 6.1(b) |