200626-61-5

200626-61-5 structure

Name: ITSA-1
Chemical Name: benzotriazol-1-yl-(2,4-dichlorophenyl)methanone
CAS Number: 200626-61-5
Molecular Formula: C₁₃H₇Cl₂N₃O
Molecular Weight: 292.12000
Catalog: Research Areas Cancer
Create Date: 2017-10-16 08:50:05
Modify Date: 2024-01-10 16:33:01
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target：TSA.In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells.

Name	benzotriazol-1-yl-(2,4-dichlorophenyl)methanone
Synonyms	ITSA-1 Inhibitor of Trichostatin A 1 Inhibitor-1 of Trichostatin A

Description	ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target：TSA.In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells.
Related Catalog	Research Areas >> Cancer
Target	HDAC
References	[1]. Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10(5):397-410.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%