ITSA-1
Modify Date: 2024-01-10 16:33:01
ITSA-1 structure
|
Common Name | ITSA-1 | ||
|---|---|---|---|---|
| CAS Number | 200626-61-5 | Molecular Weight | 292.12000 | |
| Density | 1.51g/cm3 | Boiling Point | 483.4ºC at 760 mmHg | |
| Molecular Formula | C13H7Cl2N3O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 246.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of ITSA-1ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target：TSA.In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells. |
| Name | benzotriazol-1-yl-(2,4-dichlorophenyl)methanone |
|---|---|
| Synonym | More Synonyms |
| Description | ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target：TSA.In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells. |
|---|---|
| Related Catalog | |
| Target |
HDAC |
| References |
| Density | 1.51g/cm3 |
|---|---|
| Boiling Point | 483.4ºC at 760 mmHg |
| Molecular Formula | C13H7Cl2N3O |
| Molecular Weight | 292.12000 |
| Flash Point | 246.2ºC |
| Exact Mass | 290.99700 |
| PSA | 47.78000 |
| LogP | 3.42660 |
| Vapour Pressure | 1.68E-09mmHg at 25°C |
| Index of Refraction | 1.706 |
| Storage condition | -20℃ |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| ITSA-1 |
| Inhibitor of Trichostatin A 1 |
| Inhibitor-1 of Trichostatin A |