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486-64-6

486-64-6 structure
486-64-6 structure
  • Name: Vasicinone
  • Chemical Name: vasicinone
  • CAS Number: 486-64-6
  • Molecular Formula: C11H10N2O2
  • Molecular Weight: 202.209
  • Catalog: Natural product Alkaloid
  • Create Date: 2018-02-14 08:00:00
  • Modify Date: 2025-08-25 18:47:32
  • Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].
Name vasicinone
Synonyms (3S)-3-Hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Pyrrolo[2,1-b]quinazolin-9(1H)-one, 2,3-dihydro-3-hydroxy-, (3S)-
Vasicinone
L-vasicinone
Description Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].
Related Catalog
In Vitro Vasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1]. Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1]. Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 1~30 µM Incubation Time: 24 hours Result: Significantly reversed the paraquat-induced reduction in cell viability. Western Blot Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway. Apoptosis Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Dose-dependently reduced the percentage of apoptotic cells.
References

[1]. Ju DT, et al. Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson's Disease-Associated SH-SY5Y Cell Model. Nutrients. 2019;11(7):1655. Published 2019 Jul 19.
Density 1.5±0.1 g/cm3
Boiling Point 409.8±47.0 °C at 760 mmHg
Melting Point 200-202ºC
Molecular Formula C11H10N2O2
Molecular Weight 202.209
Flash Point 201.7±29.3 °C
Exact Mass 202.074234
PSA 55.12000
LogP -0.40
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.743
Storage condition 2-8℃
Hazard Codes Xi
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title: CAS No. 486-64-6 | Chemsrc address: https://www.chemsrc.com/en/baike/1102741.html

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