Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Hydroxylamine, O-(carboxymethyl)-
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Purity: 98.0%
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645-88-5

645-88-5 structure

645-88-5 structure

Name: Hydroxylamine, O-(carboxymethyl)-
Chemical Name: (aminooxy)acetate
CAS Number: 645-88-5
Molecular Formula: C₂H₅NO₃
Molecular Weight: 91.07
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2016-09-15 16:09:08
Modify Date: 2024-01-03 11:42:52
Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.

Name	(aminooxy)acetate
Synonyms	MFCD01671589

Description	Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	MAS[1], GABA-T[2]
In Vitro	Aminooxyacetic acid (AOAA) 剂量依赖性地降低 C6 神经胶质瘤细胞的存活。Aminoxyacetic acid 处理使停滞在 G0/G1 期的细胞百分比显着增加，并使处于 S 期和 G2/M 期的细胞百分比显着降低。Aminoxyacetic acid 处理导致处于细胞分裂期的细胞数量明显减少。Aminoxyacetic acid 显着增加早期细胞凋亡和坏死的百分比。用 1mM 或 5mM Aminoxyacetic acid 处理细胞可降低细胞老化水平[1]。与谷氨酰胺依赖性较低的细胞相比，Aminoxyacetic acid (AOA) 对谷氨酰胺依赖性细胞系生长的抑制作用更大[3]。
In Vivo	GABA 在小脑和整个大脑中的积累最初非常迅速，在注射 Aminooxyacetic acid (AOAA) 后 5 分钟就已经显著增加。Aminooxyacetic acid 处理后 2 至 6 小时，GABA 快速的初始积累逐渐变慢并达到最大水平（对照水平的 400 至 600%）。Aminooxyacetic acid 处理后 24 小时，GABA 水平升高了约 250%。Aminooxyacetic acid 处理后 2-6小时，惊厥完全阻断。Aminooxyacetic acid 处理后 24 小时，惊厥与对照组几乎相同[2]。
References	[1]. Wang C, et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378(1):1-7. [2]. Pagliusi SR, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):210-5. [3]. Korangath P, et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res. 2015 Jul 15;21(14):3263-73.

Density	1.375g/ml
Boiling Point	327℃
Melting Point	138℃
Molecular Formula	C₂H₅NO₃
Molecular Weight	91.07
Flash Point	151℃
Exact Mass	90.01910
PSA	75.38000

Hazard Codes	Xi

Precursor 0
DownStream 8
35048-47-6 5382-89-8 37654-41-4 10190-93-9
1205-09-0 5740-47-6 5251-93-4 6169-23-9